Annual report pursuant to Section 13 and 15(d)

Stock Options and Warrants (Details 2)

v3.8.0.1
Stock Options and Warrants (Details 2) - USD ($)
12 Months Ended
Dec. 31, 2017
Dec. 31, 2016
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]    
Stock based compensation expense $ 883,000 $ 1,327,000
Research and development [Member]    
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]    
Stock based compensation expense 420,000 535,000
General and administrative [Member]    
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]    
Stock based compensation expense $ 463,000 $ 792,000