General form of registration statement for all companies including face-amount certificate companies

Stock Options and Warrants (Details 4)

v3.6.0.2
Stock Options and Warrants (Details 4) - USD ($)
3 Months Ended 9 Months Ended 12 Months Ended
Sep. 30, 2016
Sep. 30, 2015
Sep. 30, 2016
Sep. 30, 2015
Dec. 31, 2015
Dec. 31, 2014
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]            
Stock based compensation expense $ 300,000 $ 372,000 $ 1,027,000 $ 1,113,000 $ 1,485,000 $ 3,460,000
Research and development [Member]            
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]            
Stock based compensation expense 113,000 148,000 423,000 443,000 583,000 1,435,000
General and administrative [Member]            
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]            
Stock based compensation expense $ 187,000 $ 224,000 $ 604,000 $ 670,000 $ 902,000 $ 2,025,000